All PET studies were performed using a GE Discovery STE PET/CT scanner (GE Medical Systems, Milwaukee, Wisconsin) at the PET Center, Children’s Hospital of Michigan, Detroit Medical Center. The PET image in-plane resolution was 7.5 ± 0.4 mm at full-width half-maximum (FWHM) and 7.0 ± 0.5 mm FWHM in the axial direction and a slice thickness of 3.125 mm. The procedure for AMT-PET scanning has been described previously.13 (link),28 (link),30 (link)-32 (link, link) In brief, after 6 hours of fasting, a slow bolus of AMT (37 MBq/kg) was injected via a venous line. At 25 minutes after AMT injection, a dynamic emission scan of the brain (7× 5 minutes) was acquired. Measured attenuation correction, scatter, and decay correction were applied to all PET images. For measurement of AMT uptake, averaged activity images 30 to 55 minutes postinjection were created and converted to an AMT standardized uptake value (SUV) image.
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PET Imaging of AMT Uptake in Brain
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Corresponding Organization : The Barbara Ann Karmanos Cancer Institute
Other organizations : Virginia Tech, Carilion Clinic
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Variable analysis
independent variables
- None explicitly mentioned
- AMT standardized uptake value (SUV)
- GE Discovery STE PET/CT scanner (GE Medical Systems, Milwaukee, Wisconsin) at the PET Center, Children's Hospital of Michigan, Detroit Medical Center
- PET image in-plane resolution of 7.5 ± 0.4 mm at full-width half-maximum (FWHM) and 7.0 ± 0.5 mm FWHM in the axial direction and a slice thickness of 3.125 mm
- 6 hours of fasting
- Slow bolus of AMT (37 MBq/kg) injection via a venous line
- Dynamic emission scan of the brain (7× 5 minutes) starting 25 minutes after AMT injection
- Measured attenuation correction, scatter, and decay correction applied to all PET images
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