To determine the correlation between single gene expression and clinical characteristics and prognosis of glioma patients, we conducted univariate and multivariate independent prognostic analysis on gene expression profile, clinical profile, and survival profile in CGGA and GSE43378 by Cox regression method using survival R package. The clinical profile of glioma patients in CGGA and GSE43378 are shown in Table 1 . We further screened out clinical characteristics relating to glioma prognosis and determined the prognostic value of the single gene, p<0.05 was considered statistically significant.
Clinical Characteristics of Patients with Glioma in CGGA and GSE43378
| Parameters | CGGA (N=749) | GSE43378 (N=50) |
|---|---|---|
| Age | ||
| <=41, n (%) | 342(45.7) | 12(24.0) |
| >41, n (%) | 407(54.3) | 38(76.0) |
| Gender | ||
| Female, n (%) | 307(41.0) | 16(32.0) |
| Male, n (%) | 442(59.0) | 34(68.0) |
| Radio | ||
| No, n (%) | 124(16.6) | – |
| Yes, n (%) | 625(83.4) | – |
| Chemo | ||
| No, n (%) | 229(30.6) | – |
| Yes, n (%) | 520(69.4) | – |
| Histology | ||
| Astrocytoma (A), n (%) | 75(10.0) | 5(10.0) |
| Anaplastic astrocytoma (AA), n (%) | 75(10.0) | 7(14.0) |
| Anaplastic oligodendroglioma (AO), n (%) | 37(04.9) | 4(08.0) |
| Anaplastic oligoastrocytoma (AOA), n (%) | 128(17.1) | 2(04.0) |
| Oligodendroglioma (O), n (%) | 39(05.2) | – |
| Oligoastrocytoma (OA), n (%) | 104(13.9) | – |
| Glioblastoma (GBM), n (%) | 291(38.9) | 32(64.0) |
| PRS_type | ||
| Primary, n (%) | 502(67.0) | – |
| Recurrent, n (%) | 222(29.7) | – |
| Secondary, n (%) | 25(03.3) | – |
| Grade | ||
| WHO II, n (%) | 218(29.1) | 5(10.0) |
| WHO III, n (%) | 240(32.0) | 13(26.0) |
| WHO IV, n (%) | 291(38.9) | 32(64.0) |
| IDH_mutation | ||
| Wildtype, n (%) | 339(45.3) | – |
| Mutant, n (%) | 410(54.7) | – |
| 1p19q_codeletion | ||
| Non-codel, n (%) | 594(79.3) | – |
| Codel, n (%) | 155(20.7) | – |
| Survival state | ||
| Live, n (%) | 293(39.1) | 8(16.0) |
| Dead, n (%) | 456(60.9) | 42(84.0) |
