90Y SIRT Imaging Protocol at Oxford

Data from 10 patients treated with ${}^{90}$ Y SIRT were acquired at Oxford University Hospitals NHS Foundation Trust (OUH), UK, using the GE Discovery 670 for SPECT/CT data and GE Discovery 710 for PET/CT data. The cases were a mixture of treatments with SIR-Spheres (SIRTeX) ( $n=6$ ) and TheraSpheres (BTG) ( $n=4$ ) [29 (link)]. Images were acquired approximately 18 h following SIRT administration with PET/CT followed by SPECT/CT. The SPECT data were acquired for 30 min using a medium energy collimator and a energy window range 50–150 keV [30 (link)]. The PET data were acquired for 15 min per bed position with two bed positions acquired [29 (link), 31 (link)]. Figure 2 shows the CT, SPECT and PET images of one patient.Fig. 2

Magnified CT, SPECT and PET images for patient 1 with volume of interests. The CT and SPECT images are the one used as side information for HKEM and MHKEM. L1 is a lesion in the proximity of the liver surface, L2 is a lesion with the maximum voxel value, and BGR is the background VOI. On the top row, the segmented VOI is superimposed to the fused PET-CT image. The fused images are magnified to better show the VOIs