C57/Bl6, Drd1-EGFP, Drd2-EGFP, and α2-knockout mice (Glra2-KOs) of the age of 8–16 weeks were used in the study. Glra2-KOs were generated by deletion of the exon 7 of Glra2 (Avila et al., 2013b (link)). Drd1-EGFP and Drd2-EGFP (Gong et al., 2003 (link)) mouse lines were obtained from Jackson Laboratory. Glra2-KOs were fully back-crossed to C57/Bl6, and Drd1a-EGFP and Drd2-EGFP to CD1 background and genotyped as described previously (Gong et al., 2003 (link); Avila et al., 2013b (link)). C57/Bl6, Drd1-EGFP, and Drd2-EGFP mice of both sexes and Glra2-KO and WT males were used in the study.
All experimental procedures were performed according to the Institutional Animal Care Committee guidelines and were approved by local ethics committees. All efforts were made to minimize the suffering and number of animals used.
All experimental procedures were performed according to the Institutional Animal Care Committee guidelines and were approved by local ethics committees. All efforts were made to minimize the suffering and number of animals used.
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