The C57BL/6 mice used in this study were bred and housed in a specific pathogen-free animal facility at Sun Yat-Sen University. The mice were kept in a controlled 12-hour light and 12-hour dark cycle. Random assignment of the mice to different experimental groups was done for follow-up experiments. All animal procedures conducted in this study were performed in compliance with the guidelines for the treatment of laboratory animals and approved by the Institutional Animal Care and Use Committee of Sun Yat-Sen University.
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