Formulation and Characterization of ENZ Tablets

ENZ was purchased from MSN Laboratories Private Ltd. (Telangana, India). Copovidone (Abbreviated as Kollidon VA64) and colloidal silica were supplied by Boryung Pharmaceutical. Co., Ltd. (Seoul, Republic of Korea). Hydroxypropylcellulose (Abbreviated as HPC-L) was supplied by Cosmax Pharmaceutical. Co., Ltd. (Cheongju, Republic of Korea). Hydroxypropylmethylcellulose phthalate (HPMCP HP55) was provided by Hanmi Pharmaceutical. Co., Ltd. (Seoul, Republic of Korea). N,N-dimethylaminoethyl methacrylate (abbreviated as Eudragit E PO) was obtained from Evonik (Essen, Germany). Propylene glycol dicaprylocaprate (abbreviated as Labrafa PG) and Diethylene glycol monoethyl ether (abbreviated as Transcutol P) were acquired from Gattefosse (St. Priest, France). Macrogoli 15 hydroxystearas (abbreviated as Solutol HS15) was sourced from BASF (Ludwigshafen, Germany). Sodium carboxymethyl cellulose was purchased from Duksan Chemicals (Ansan, Republic of Korea). Acetonitrile, ammonium acetate, and acetone were purchased from Daejung Chemicals (Siheung, Republic of Korea). Other chemicals used were of the appropriate class for analysis.

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Lee S.M., Lee J.G., Yun T.H., Kim C.H., Cho J.H, & Kim K.S. (2024). The Impact of Polymers on Enzalutamide Solid Self-Nanoemulsifying Drug Delivery System and Improved Bioavailability. Pharmaceutics, 16(4), 457.

Publication 2024

Eudragit E PO Propylene glycol dicaprylocaprate Diethylene glycol monoethyl ether Acetonitrile ammonium acetate acetone

Corresponding Organization : Dankook University

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Variable analysis

independent variables

ENZ (purchased from MSN Laboratories Private Ltd.)
Copovidone (Kollidon VA64, supplied by Boryung Pharmaceutical. Co., Ltd.)
Colloidal silica (supplied by Boryung Pharmaceutical. Co., Ltd.)
Hydroxypropylcellulose (HPC-L, supplied by Cosmax Pharmaceutical. Co., Ltd.)
Hydroxypropylmethylcellulose phthalate (HPMCP HP55, provided by Hanmi Pharmaceutical. Co., Ltd.)
N,N-dimethylaminoethyl methacrylate (Eudragit E PO, obtained from Evonik)
Propylene glycol dicaprylocaprate (Labrafa PG, acquired from Gattefosse)
Diethylene glycol monoethyl ether (Transcutol P, acquired from Gattefosse)
Macrogoli 15 hydroxystearas (Solutol HS15, sourced from BASF)
Sodium carboxymethyl cellulose (purchased from Duksan Chemicals)

dependent variables

Not explicitly mentioned

control variables

Acetonitrile, ammonium acetate, and acetone (purchased from Daejung Chemicals)

controls

No positive or negative controls were explicitly mentioned.

Annotations

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