Murine intracranial aneurysms were created in female 8-12 week-old C57BL/6 mice (Charles River Laboratories, Wilmington, MA) using a method described previously.10 (link) For the antibody blockade, 100 μg/mL anti-CXCL1 antibody (MAB453, R&D Systems) or 100 μg/mL IgG2A control antibody were injected retro-orbitally every two days.
Protocol detail
Murine Intracranial Aneurysm Model
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Anti antibody
Antibody
Antibody blockade
C57bl mice
Cxcl1
Female
Igg2a
Intracranial aneurysms
Murine
River
Corresponding Organization :
Other organizations : University of Florida
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Variable analysis
independent variables
- Anti-CXCL1 antibody (MAB453, R&D Systems)
- IgG2A control antibody
- Murine intracranial aneurysms
- Female 8-12 week-old C57BL/6 mice (Charles River Laboratories, Wilmington, MA)
- Positive control: 100 μg/mL IgG2A control antibody
- Negative control: not explicitly mentioned
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