Bladder Cancer BCG Treatment Protocol

The BCG treatment protocol has been previously reported.^{22 (link)} In brief, patients received 1 vial of BCG TICE strain (Organon Teknika Corporation) with or without 50 million U of interferon α-2b (IFN-α-2b) instilled simultaneously into the bladder for approximately 90 to 120 minutes. The starting BCG dose of the induction cycle was altered to one-third of the dose during times when BCG availability was limited at our institution or when a patient experienced substantial lower urinary tract symptoms before treatment. The BCG maintenance regimen consisted of a reduced (one-third to one-tenth) dose administered over three 3-week courses at 3 months, 9 months, and 15 months after the end of the last induction treatment, as previously described.^{22 (link)}