Lapatinib and Trastuzumab Stock Preparation

Lapatinib and trastuzumab were purchased from LC Laboratories and Mckesson Specialty Health, respectively. Stocks of L and T were prepared as described previously (10 (link), 19 (link)). Afatinib (Afa) and neratinib (Nrb) were purchased from LC Laboratories and Selleck Chemicals, respectively. Stocks of Afa and Nrb were prepared with DMSO.

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Xu X., De Angelis C., Burke K.A., Nardone A., Hu H., Qin L., Veeraraghavan J., Sethunath V., Heiser L.M., Wang N., Ng C.K., Chen E.S., Renwick A., Wang T., Nanda S., Shea M., Mitchell T., Rajendran M., Waters I., Zabransky D.J., Scott K.L., Gutierrez C., Nagi C., Geyer F.C., Chamness G.C., Park B.H., Shaw C.A., Hilsenbeck S.G., Rimawi M.F., Gray J.W., Weigelt B., Reis-Filho J.S., Osborne C.K, & Schiff R. (2017). HER2 Reactivation through Acquisition of the HER2 L755S Mutation as a Mechanism of Acquired Resistance to HER2-targeted Therapy in HER2+ Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research, 23(17), 5123-5134.

Publication 2017

Lapatinib Afatinib neratinib

Afatinib Dmso Lapatinib Neratinib Trastuzumab

Corresponding Organization : Baylor College of Medicine

Other organizations : Memorial Sloan Kettering Cancer Center, Oregon Health & Science University, Sidney Kimmel Comprehensive Cancer Center

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Variable analysis

independent variables

Lapatinib (L)
Trastuzumab (T)
Afatinib (Afa)
Neratinib (Nrb)

dependent variables

Not explicitly mentioned

control variables

Not explicitly mentioned

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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