Histopathological Examination of Infected Mice

All histopathological examination was performed by a pathologist that was not blinded to each specimen’s treatment group. Paraformaldehyde-fixed organ segments from infected mice were paraffin-embedded and stained with hematoxylin and eosin (H&E) for cellular composition as previously described32 (link). Stained sections were analyzed and photographed using a Nikon Microphot-FX photomicrographic system with NIS-Elements F3.0 software (Nikon Instruments Inc, Melville, NY).

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Shatzkes K., Chae R., Tang C., Ramirez G.C., Mukherjee S., Tsenova L., Connell N.D, & Kadouri D.E. (2015). Examining the safety of respiratory and intravenous inoculation of Bdellovibrio bacteriovorus and Micavibrio aeruginosavorus in a mouse model. Scientific Reports, 5, 12899.

Publication 2015

Microphot-FX NIS-Elements F3.0

Cellular Eosin Mice Paraffin Paraformaldehyde Pathologist Photomicrographic Specimen treatment

Corresponding Organization :

Other organizations : Rutgers, The State University of New Jersey, New York City College of Technology

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Variable analysis

independent variables

Treatment group

dependent variables

Cellular composition

control variables

Paraformaldehyde-fixation of organ segments
Paraffin-embedding of organ segments
Hematoxylin and eosin (H&E) staining of sections

controls

No explicit mention of positive or negative controls

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