All patients underwent both AVS and MTO. The order that each participant underwent each investigation was determined by a minimization program within the study data center (Robertson Centre for Biostatistics, University of Glasgow), designed to maintain a balance with respect to study site, sex and age (<55 or ≥55 years). Both AVS and MTO were performed with the patient taking non-interfering medications such as doxazosin, verapamil and hydralazine, according to Endocrine Society consensus guidelines11 (link).
Wu X., Senanayake R., Goodchild E., Bashari W.A., Salsbury J., Cabrera C.P., Argentesi G., O’Toole S.M., Matson M., Koo B., Parvanta L., Hilliard N., Kosmoliaptsis V., Marker A., Berney D.M., Tan W., Foo R., Mein C.A., Wozniak E., Savage E., Sahdev A., Bird N., Laycock K., Boros I., Hader S., Warnes V., Gillett D., Dawnay A., Adeyeye E., Prete A., Taylor A.E., Arlt W., Bhuva A.N., Aigbirhio F., Manisty C., McIntosh A., McConnachie A., Cruickshank J.K., Cheow H., Gurnell M., Drake W.M, & Brown M.J. (2023). [11C]metomidate PET-CT versus adrenal vein sampling for diagnosing surgically curable primary aldosteronism: a prospective, within-patient trial. Nature Medicine, 29(1), 190-202.
Other organizations :
Queen Mary University of London, William Harvey Research Institute, Wellcome/MRC Institute of Metabolic Science, University of Cambridge, Barts Health NHS Trust, St Bartholomew's Hospital, Cambridge University Hospitals NHS Foundation Trust, Addenbrooke's Hospital, National University Heart Centre Singapore, National University of Singapore, Guy's and St Thomas' NHS Foundation Trust, University of Birmingham, University of Glasgow
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