AFM Imaging of Amyloid Fibrils
Corresponding Organization : AstraZeneca (United Kingdom)
Other organizations : University of Cambridge, University College London, National Hospital for Neurology and Neurosurgery
Variable analysis
- Incubation time of cleaved mica surfaces with (3-aminopropyl)triethoxysilane solution (1 min)
- Fibril heights measured using AFM
- Concentration of (3-aminopropyl)triethoxysilane solution (0.5% v/v)
- Volume of sample solution deposited on the mica surface (10 μL)
- Incubation time of sample solution on the mica surface (10 min)
- Rinsing procedure with deionized water (3 times with 1 mL)
- Drying method using a gentle stream of nitrogen
- Room temperature for all procedures
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