Resting-state fMRI Data Collection and Processing

For the COBRE dataset, the MRI Images were collected on a single 3-Tesla Siemens Trio scanner with a 12-channel radiofrequency coil. High resolution T2^*-weighted functional images were acquired using a gradient-echo echo-planar imaging (EPI) sequence with TE = 29 ms, TR = 2 s, flip angle = 75°, slice thickness = 3.5 mm, slice gap = 1.05 mm, field of view = 240 mm, matrix size = 64, voxel size = 3.75 × 3.75 × 4.55 mm³. Resting-state scans consisted of 149 volumes. Subjects were instructed to keep their eyes open during the resting-state scan and stare passively at a central cross (Aine et al., 2017 (link)). For the FBIRN dataset, six sites used 3T Siemens TIM Trio scanners, and one site used a 3T GE MR750 scanner for collecting the imaging data. All sites used the following T2^*-weighted AC-PC aligned EPI sequence: TR = 2 s, TE = 30 ms, flip angle = 77°, slice gap = 1 mm, voxel size = 3.4 × 3.4 × 4 mm³, number of frames = 162, acquisition time = 5 min and 38 s (van Erp et al., 2015 (link)).