Comprehensive Data Collection for Respiratory Infection Study
Data collection of this TTT-study was described previously [13 (link)]. In short, all available clinical data (including biomarkers tested for routine care, a study specific nasal swab and information from a 28-day follow-up assessment) was recorded in an electronic Case Report Form (eCRF) [13 (link)]. A multiplex PCR-based assay of the 14 most common respiratory pathogens (nine viruses, five bacteria) was performed on all nasal swabs (MagnaPure LC total nucleic acid kit and MagnaPure 96 DNA, Roche Diagnostics, Mannheim, Germany) [15 (link)]. The PCR results were not available for the attending physician, since this assay was performed after completion of the recruitment process.
van Houten C.B., Cohen A., Engelhard D., Hays J.P., Karlsson R., Moore E., Fernández D., Kreisberg R., Collins L.V., de Waal W., de Winter-de Groot K.M., Wolfs T.F., Meijers P., Luijk B., Oosterheert J.J., Heijligenberg R., Sankatsing S.U., Bossink A.W., Stubbs A., Stein M., Reisfeld S., Klein A., Rachmilevitch R., Ashkar J., Braverman I., Kartun V., Chistyakov I., Bamberger E., Srugo I., Odeh M., Schiff E., Dotan Y., Boico O., Navon R., Friedman T., Etshtein L., Paz M., Gottlieb T.M., Pri-Or E., Kronenfeld G., Simon E., Oved K., Eden E, & Bont L.J. (2019). Antibiotic misuse in respiratory tract infections in children and adults—a prospective, multicentre study (TAILORED Treatment). European Journal of Clinical Microbiology & Infectious Diseases, 38(3), 505-514.
Other organizations :
University Medical Center Utrecht, Utrecht University, Tirat Carmel Mental Health Center, MeMed (Israel), Hadassah Medical Center, Erasmus MC, University of Gothenburg, Noray Bioinformatics (Spain), Diakonessenhuis hospital, Ziekenhuis Gelderse Vallei, Hillel Yaffe Medical Center, Bnai Zion Medical Center
Presence of respiratory pathogens detected by multiplex PCR-based assay
dependent variables
Clinical data (including biomarkers tested for routine care, a study specific nasal swab and information from a 28-day follow-up assessment)
control variables
PCR results were not available for the attending physician, since this assay was performed after completion of the recruitment process
controls
Positive control: Not specified
Negative control: Not specified
Annotations
Based on most similar protocols
Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.
As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to
get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
