Correlating Drug Response with Cancer Functional Events
For each drug an ANOVA model was fitted to correlate drug response with the status of Cancer Functional Events (CFEs), as described in Garnett et al. (2012) (link), implemented in GDSCtools (http//gdsctools.readthedocs.io) and detailed in the the Supplemental Experimental Procedures. The downsampling ANOVA simulation studies are detailed in the Supplemental Experimental Procedures. We applied the LOBICO (Knijnenburg et al., 2016 ) framework as detailed in the Supplemental Experimental Procedures. Machine learning models were computed as detailed in the Supplemental Experimental Procedures.
Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Gonçalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X., Egan R.K., Liu Q., Mironenko T., Mitropoulos X., Richardson L., Wang J., Zhang T., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F., Saez-Rodriguez J., McDermott U, & Garnett M.J. (2016). A Landscape of Pharmacogenomic Interactions in Cancer. Cell, 166(3), 740-754.
Publication 2016
Anova Cancer drug Drug
Corresponding Organization : Wellcome Sanger Institute
Other organizations :
European Bioinformatics Institute, Institute for Systems Biology, Oncode Institute, The Netherlands Cancer Institute, RWTH Aachen University, Joint Research Centre, Delft University of Technology, Center for Cancer Research, Harvard University, Massachusetts General Hospital, Bristol-Myers Squibb (United States), Institut d'Investigació Biomédica de Bellvitge, Dana-Farber Cancer Institute, Municipal Institute for Medical Research, Pompeu Fabra University, Hospital del Mar Research Institute, Institució Catalana de Recerca i Estudis Avançats, Universitat de Barcelona, Howard Hughes Medical Institute, Cancer Genomics Centre
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