Evaluating Zoledronic Acid Safety

Information on any ARs, laboratory tests, and other measurements, especially of renal function and serum calcium, was collected. In association with the use of ZOL, the following conditions were included as the known, important risks: predefined acute-phase reaction (APR: pyrexia, malaise, arthralgia, myalgia, nausea, vomiting, influenza-like illness, headache, diarrhea, bone pain, pain in an extremity, and acute-phase reaction as reported by the attending physician), renal function-related ARs, hypocalcaemia, osteonecrosis of the jaw, and atypical femoral fracture. Any events were classified according to MedDRA ver. 23.0.

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Takada J., Sato S., Arai K., Kito Y., Oshita Y, & Saito K. (2023). Safety and effectiveness of once-yearly zoledronic acid in Japanese osteoporosis patients: three-year post-marketing surveillance. Journal of Bone and Mineral Metabolism, 41(2), 268-277.

Publication 2023

Acute phase reaction Arthralgia Bone Calcium Diarrhea Femoral fracture Headache Hypocalcaemia Influenza Myalgia Nausea Osteonecrosis Pain Physician Pyrexia Renal Serum

Corresponding Organization :

Other organizations : Sapporo Science Center, Asahi Kasei (Japan)

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Variable analysis

independent variables

Use of ZOL

dependent variables

Predefined acute-phase reaction (APR: pyrexia, malaise, arthralgia, myalgia, nausea, vomiting, influenza-like illness, headache, diarrhea, bone pain, pain in an extremity, and acute-phase reaction as reported by the attending physician)
Renal function-related adverse reactions
Hypocalcaemia
Osteonecrosis of the jaw
Atypical femoral fracture

control variables

Not explicitly mentioned

controls

Not explicitly mentioned

Annotations

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