Longitudinal Functional Brain Connectivity

Participants were recruited and participated between April 2011 and April 2019. A total of 86 participants were included in this portion of the study, including 21 SZ, 26 GHR, and 39 HC. At baseline, the mean age was 25.93 (7.65) years, aged 13–45 years. There were no significant differences in age among the SZ, GHR, and HC groups; however significant differences were observed in sex (χ² = 12.82, p = 0.002). All participants underwent clinical and resting state functional MRI (R-fMRI) assessment at baseline and follow-up at least 10 months after initial scan (ranged 11–67 months). The mean duration between baseline and follow-up scans was 26.16 (14.28) months. Diagnoses were confirmed again at follow-up (using SCID or K-SADS-PL) with no diagnostic change for any participants.

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Duan J., Gong X., Womer F.Y., Sun K., Tang L., Liu J., Zheng J., Zhu Y., Tang Y., Zhang X, & Wang F. (2023). Neurodevelopmental trajectories, polygenic risk, and lipometabolism in vulnerability and resilience to schizophrenia. BMC Psychiatry, 23, 153.

Publication 2023

Diagnostic Fmri Sads Scans Scid

Corresponding Organization : Nanjing Medical University

Other organizations : Nanjing Brain Hospital, Fudan University, Vanderbilt University Medical Center, First Hospital of China Medical University, China Medical University

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Variable analysis

independent variables

Participant group (SZ, GHR, HC)

dependent variables

Resting state functional MRI (R-fMRI) measurements at baseline and follow-up
Clinical assessments at baseline and follow-up

control variables

Age of participants
Time between baseline and follow-up scans (ranged 11-67 months, mean 26.16 ± 14.28 months)

controls

Positive control: Diagnosis confirmation at follow-up using SCID or K-SADS-PL, with no diagnostic change for any participants

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