The control group was given FOLFOX4 chemotherapy regimen [12 (link)]: oxaliplatin injection (batch number HIE09099003, Qilu Pharmaceutical Co., Ltd.) 85 mg/m2 was given intravenously for 2 hours on day 1, 2 h intravenous drip of leucovorin injection (batch number 1002923, Jiangsu Hengrui Pharmaceutical Co., Ltd.) 200 mg/m2, intravenous bolus injection of 5-fluorouracil (batch number 090709, Shanghai Xu Donghaipu Pharmaceutical Co., Ltd.) 400 mg/m2, followed by continuous 2 h intravenous 5-fluorouracil 600 mg/m2 on days 1 and 2. One course of treatment was repeated every 2 weeks, with a total of 4 courses of treatment.
The patients in the observation group were treated with modified Yiwei Shengyang decoction plus FOLFOX4 chemotherapy (same as the control group). The components of the modified Yiwei Shengyang decoction include Astragalus, Codonopsis 30 g, Poria 20 g, 15 g each of white peony root, bark lotus, Hedyotis diffusa, and Atractylodes, 10 g each of tangerine peel, Saposhnicovia divaricata, Pinellia, Alisma, and 5 g licorice, decocted with water, 1 dose/d and taken 0.5 h after breakfast and dinner. A course spans 14 days, and 3 courses of treatment were given. The patients were routinely treated with antiallergy, hydration diuresis and antiemetic symptomatic treatment according to the daily observation.
Free full text: Click here