Endometrial Cancer Immunohistochemistry Study

The patient cohort used herein consists of 47 EC, 20 SEH, 12 CEH and 38 specimens of normal endometrium that underwent surgery at the First Affiliated Hospital of Anhui Medical University (AMU) (Hefei, Anhui, People's Republic of China) between 2001 and 2002 as previously described [58 (link)]. The Institutional Review Board of AMU approved the protocol for the use of patient specimens in this study [58 (link)]. Patient consent forms were obtained from all patients in accordance with the Declaration of Helsinki [58 (link)]. IHC analysis was performed as previously described [58 (link)] using rabbit anti-TFF3 was obtained from Abcam, Cambridge, MA; rabbit anti-SP1, rabbit anti-p-c-JUN and rabbit anti-c-JUN antibodies wereobtained from Cell Signaling Technology, Singapore [17 (link)]. The details of the cohort and IHC scoring methodology have previously been described in detail [30 (link), 58 (link), 59 (link)].

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Pandey V., Zhang M., Chong Q.Y., You M., Raquib A.R., Pandey A.K., Liu D.X., Liu L., Ma L., Jha S., Wu Z.S., Zhu T, & Lobie P.E. (2017). Hypomethylation associated enhanced transcription of trefoil factor-3 mediates tamoxifen-stimulated oncogenicity of ER+ endometrial carcinoma cells. Oncotarget, 8(44), 77268-77291.

Publication 2017

rabbit anti-TFF3 rabbit anti-SP1 rabbit anti-p-c-JUN rabbit anti-c-JUN

Anti c antibodies Endometrium Institutional review board Patients Rabbit Surgery

Corresponding Organization : University of Science and Technology of China

Other organizations : National University Cancer Institute, Singapore, National University of Singapore, Auckland University of Technology, Fudan University Shanghai Cancer Center, Tsinghua–Berkeley Shenzhen Institute, Tsinghua University, Anhui Medical University

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Variable analysis

independent variables

Endometrial Cancer (EC)
Secretory Endometrial Hyperplasia (SEH)
Complex Endometrial Hyperplasia (CEH)

dependent variables

Expression of TFF3, SP1, p-c-JUN, and c-JUN

control variables

Normal endometrium

controls

Positive control: Not explicitly mentioned.
Negative control: Not explicitly mentioned.

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