In this retrospective case-control study, all patients with KD were enrolled between August 2017 and August 2022 at Wuhan Children's Hospital. The diagnosis criteria for KD were based on the guideline issued by the Japan Kawasaki Disease Research Committee in 2020 (16 (link)). MAS diagnosis was made according to the MAS-sJIA-2016 criteria (17 (link)).
Inclusion criteria: (1) individuals younger than 18 years (2); complete or incomplete KD was diagnosed (3); MAS was diagnosed based on the diagnostic criteria. Exclusion criteria: (1) individuals without complete medical records (2); hospitalization for less than 24 h and referral to other hospitals (3); treatment with IVIG or steroids in other hospitals before admission.
Individuals were divided into two groups based on their clinical outcome: KD and KD-MAS groups. In total, 28 cases satisfied the KD-MAS criteria. In the KD group, 4 control cases were chosen for each patient and matched to its control by admission time (±1 week) as the matching factor to control for the effect of seasonal factor (18 (link), 19 (link)). This study was approved by the Ethics Committee of Wuhan Children's Hospital.
Our primary objective was to investigate the early predictor factors for KD-MAS, and the secondary objective was to evaluate the evolution of KD-MAS during medical treatment. IVIG resistance, as a potential predictor factor, was defined as persistent or recrudescent fever at least 36 h and <7 days after the completion of the first IVIG infusion (1 (link)).
Inclusion criteria: (1) individuals younger than 18 years (2); complete or incomplete KD was diagnosed (3); MAS was diagnosed based on the diagnostic criteria. Exclusion criteria: (1) individuals without complete medical records (2); hospitalization for less than 24 h and referral to other hospitals (3); treatment with IVIG or steroids in other hospitals before admission.
Individuals were divided into two groups based on their clinical outcome: KD and KD-MAS groups. In total, 28 cases satisfied the KD-MAS criteria. In the KD group, 4 control cases were chosen for each patient and matched to its control by admission time (±1 week) as the matching factor to control for the effect of seasonal factor (18 (link), 19 (link)). This study was approved by the Ethics Committee of Wuhan Children's Hospital.
Our primary objective was to investigate the early predictor factors for KD-MAS, and the secondary objective was to evaluate the evolution of KD-MAS during medical treatment. IVIG resistance, as a potential predictor factor, was defined as persistent or recrudescent fever at least 36 h and <7 days after the completion of the first IVIG infusion (1 (link)).
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