Lipidomic Profiling of Schizophrenia

A total of 298 participants, consisting of 78 SZ, 75 GHR, and 145 HC, were included in this portion of the study. Baseline measures for 51 participants from the longitudinal study were included for this portion. Blood samples were obtained within 24 h of scanning. All participants underwent venipuncture between 10:00 a.m. and 3 p.m. Venous blood samples were centrifuged at 2,000 rpm for 10 min, and then stored at -80 °C for genotyping and lipidomic measurements.

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Duan J., Gong X., Womer F.Y., Sun K., Tang L., Liu J., Zheng J., Zhu Y., Tang Y., Zhang X, & Wang F. (2023). Neurodevelopmental trajectories, polygenic risk, and lipometabolism in vulnerability and resilience to schizophrenia. BMC Psychiatry, 23, 153.

Publication 2023

Blood Venipuncture Venous blood

Corresponding Organization : Nanjing Medical University

Other organizations : Nanjing Brain Hospital, Fudan University, Vanderbilt University Medical Center, First Hospital of China Medical University, China Medical University

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Variable analysis

independent variables

Participant group (schizophrenia (SZ), genetic high-risk (GHR), healthy controls (HC))

dependent variables

Lipid measurements from blood samples

control variables

Blood samples were obtained within 24 hours of scanning
All participants underwent venipuncture between 10:00 a.m. and 3:00 p.m.
Venous blood samples were centrifuged at 2,000 rpm for 10 minutes and then stored at -80 °C for genotyping and lipidomic measurements

controls

Baseline measures for 51 participants from the longitudinal study were included for this portion of the study, which may serve as a control group

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