The Tfam+/− mice were originally derived from Tfamflox mice obtained from Dr. Navdeep Chandel (Northwestern University) and generated as described previously4 (link),29 (link). The Stat1−/− mice30 (link) and female athymic nu/nu mice (Hsd:Athymic Nude-Foxn1nu, Envigo, Huntingdon, UK) were purchased from Jackson Labs (Stock No.012606). All animal husbandry and procedures were IACUC approved by the animal care and use committees at Yale University or the Salk Institute for Biological Studies.
MC-38 colon cancer cells were purchased from ATCC. Mouse YUMMER1.7 melanoma cells were obtained from Dr. Marcus Bosenberg’s (Yale University). Mouse LM thymidine kinase- (LMTK-) cells were obtained from David Clayton (Stanford University). 293FT cells were purchased from ATCC and Lenti-x 293T cells were purchased from Takara CloneTech.