Bioavailability of Telmisartan Cocrystals

The animals were divided into two groups. Group 1 (6 animals) received pure telmisartan (1 mg/kg) with 0.5% w/v sodium carboxymethylcellulose, and Group 2 (6 animals) received optimized cocrystals (equivalent to 1 mg/kg pure telmisartan) with 0.5% w/v sodium carboxymethylcellulose. Blood samples were collected at predetermined time intervals from the retro-orbital venous plexus of the rats and centrifuged for 5 min at 10,000 rpm. The plasma was separated and drug analysis was carried out by RP-HPLC method [47 ] using the software ‘Class-Vp series version 5.03 (Shimadzu)’. The in vivo pharmacokinetic parameters such as peak plasma concentration (C_max), total area under the plasma concentration-time curve (AUC_0–∞), elimination rate constant (KE), and relative bioavailability (%) were calculated by using Kinetica software (version 4.4.1; Thermo Fisher Scientific, Waltham, MA, USA).

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Dhibar M., Chakraborty S., Basak S., Pattanayak P., Chatterjee T., Ghosh B., Raafat M, & Abourehab M.A. (2023). Critical Analysis and Optimization of Stoichiometric Ratio of Drug-Coformer on Cocrystal Design: Molecular Docking, In Vitro and In Vivo Assessment. Pharmaceuticals, 16(2), 284.

Publication 2023

Kinetica software

Animals Blood Drug Hplc Plasma Rats Sodium carboxymethylcellulose Telmisartan Venous

Corresponding Organization : Minia University

Other organizations : Birla Institute of Technology and Science - Hyderabad Campus, Birla Institute of Technology and Science, Pilani, Umm al-Qura University

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Variable analysis

independent variables

Group 1 (6 animals) received pure telmisartan (1 mg/kg) with 0.5% w/v sodium carboxymethylcellulose
Group 2 (6 animals) received optimized cocrystals (equivalent to 1 mg/kg pure telmisartan) with 0.5% w/v sodium carboxymethylcellulose

dependent variables

Peak plasma concentration (C_max)
Total area under the plasma concentration-time curve (AUC_0–∞)
Elimination rate constant (KE)
Relative bioavailability (%)

control variables

Blood samples were collected at predetermined time intervals from the retro-orbital venous plexus of the rats
Collected blood samples were centrifuged for 5 min at 10,000 rpm
The plasma was separated and drug analysis was carried out by RP-HPLC method [47 (no link found)] using the software 'Class-Vp series version 5.03 (Shimadzu)'
The in vivo pharmacokinetic parameters were calculated by using Kinetica software (version 4.4.1; Thermo Fisher Scientific, Waltham, MA, USA)

controls

No positive or negative controls were explicitly mentioned in the input protocol.

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