Forced Swim Test Protocol

The apparatus for FST involved a glass transparent cylinder measured 18 cm in diameter and 19 cm in height and filled with water (25 °C) up to 13 cm in depth. On day 1 each animal was placed in the cylinder for 15 min, and on day 2 – for 5 min (Porsolt et al. 1977). The behaviour was recorded by Biobserve Viewer III (Biobserve GmbH, Germany), and the following parameters were calculated manually: the latent period of the first floating episode and the total floating time on day 2 (Müller et al. 2017 (link); Mielenz et al. 2018 (link)).

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Chestnykh D., Graßl F., Pfeifer C., Dülk J., Ebner C., Walters M., von Hörsten S., Kornhuber J., Kalinichenko L.S., Heinrich M, & Müller C.P. (2023). Behavioural effects of APH199, a selective dopamine D4 receptor agonist, in animal models. Psychopharmacology, 240(4), 1011-1031.

Publication 2023

Biobserve Viewer III

Animal

Corresponding Organization : Universiti Sains Malaysia

Other organizations : Friedrich-Alexander-Universität Erlangen-Nürnberg

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Variable analysis

independent variables

Day (1 or 2)

dependent variables

Latent period of the first floating episode on day 2
Total floating time on day 2

control variables

Apparatus: a glass transparent cylinder with 18 cm diameter and 19 cm height
Water temperature: 25 °C
Water depth: 13 cm
Duration on day 1: 15 minutes
Duration on day 2: 5 minutes

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