Differences in the baseline clinical characteristics of the bilateral occlusion group and the malocclusion group were evaluated. The Mann-Whitney U test was used to compare differences in the continuous variables between the two groups. Where appropriate, either the Fisher exact test or chi-squared test were used to compare differences in categorical variables between the two groups. A multivariate logistic regression analysis was used to adjust for the potential confounders of age, gender, CFS on admission, APACHE II score, and neurological disorders on admission. This yielded an adjusted odds ratio (OR) for ADL loss and the occurrence of delirium after malocclusion as the primary exposure. A set of these variables was chosen a priori, based on previous reports [16 (link),17 (link),21 (link),22 (link),24 (link)] and biological plausibility. Although recent studies on ICU patients and frailty have often applied the CFS to those over 18 years of age [5 (link)] as the present study, the CFS is originally designed as a tool to assess frailty in patients over 65 years of age. Therefore, we conducted subgroup analysis for the patients 65 years or older. All statistical analyses were performed using JMP software version 13 (SAS Institute, Cary, NC, USA). A two-sided probability value of <0.05 was considered statistically significant for all analyses.
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