Example 11

Exemplary capsule shell and matrix compositions useful for producing Liquisoft capsules as described herein are shown in Table 11. Composition components are set forth by weight percentage of the total weight of the composition. Such compositions were encapsulated using rotary die encapsulation as described herein.

Formulas 20 and 21 were used as batch formulations for active lots. Formula 20 is the formulation for the amount per capsule. Formula 21 is the formulation for the amount per batch.

TABLE 13
Exemplary Liquisoft Composition
Matrix Formulation
ComponentFormula 20Formula 21
Propylene Glycol8.48.4
Polyethylene Glycol 40025.6 26.6 
Polyvinylpyrrolidone K301.61.6
Maltitol52.7 52.7 
Sucralose0.60.6
Citric Acid1.01.0
Lactic Acid1.01.0
Sodium Citrate
Mannitol
Thaumatin (Talin ®)0.50.5
Glycyrrhizic acid salts
(MagnaSweet ®)
Water7.17.1
Dextromethorphan1.01.0
Hydrobromide
Menthol0.50.5
TOTAL100%100%

Free full text: Click here