Transgenic Mouse Models in Neuroscience

Animals were maintained in an AAALAC-approved animal facility and all procedures were performed in accordance with IACUC guidelines (protocol number 17013). Pcp2/L7-Cre, Neurod1-Cre and Atoh1-Cre mice were obtained from The Jackson Laboratory (catalog numbers: 004146, 028364 and 011104). Memo1 mutant mice were generated using ES-cells from the European Conditional Mouse Mutagenesis (EUCOMM) repository as described previously (Van Otterloo et al., 2016 (link)). Mouse studies were allocated by genotype, and were not blinded.

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Jereb S., Hwang H.W., Van Otterloo E., Govek E.E., Fak J.J., Yuan Y., Hatten M.E, & Darnell R.B. (2018). Differential 3’ processing of specific transcripts expands regulatory and protein diversity across neuronal cell types. eLife, 7, e34042.

Publication 2018

Neurod1-Cre Atoh1-Cre

Animal Es cells European Genotype Iacuc Mouse Mutagenesis Neurod1

Corresponding Organization :

Other organizations : Howard Hughes Medical Institute, Rockefeller University, University of Pittsburgh, University of Colorado Anschutz Medical Campus

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Variable analysis

independent variables

Genotype of mice (Pcp2/L7-Cre, Neurod1-Cre, Atoh1-Cre, and Memo1 mutant)

dependent variables

Not explicitly mentioned

control variables

All procedures were performed in accordance with IACUC guidelines
Animals were maintained in an AAALAC-approved animal facility

controls

No positive or negative controls were explicitly mentioned

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