PET Pharmacokinetic Modeling of [18F]FDG

The MRI-based ROI was used to extract the [18F]FDG activity concentration (Bq/ml) on the PET data. PET pharmacokinetic modeling was applied using the irreversible 2TCM (PMOD v.4.3, PMOD technologies) and its suitability evaluated by Schwartz Criterion (SC), Akaike Information Criterion (AIK) and Model Selection Criterion (MSC). Furthermore, rate constants were calculated for K1, k2, k3, and macro parameters MRGlu and Flux derived. The image derived input function (idIF) was segmented from the inferior vena cava as it provides a robust estimation of the idIF (28 (link)) with special regard to the spill-in contamination from neighboring tissue when using the heart (29 (link)).

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Sellæg K., Schwienbacher R., Kranz M., Aamodt A.E., Wirsing A.M., Berge G., Hadler-Olsen E, & Magnussen S.N. (2024). 4-nitroquinoline 1-oxide-induced oral epithelial lesions exhibit time- and stage-dependent changes in the tumor immune microenvironment. Frontiers in Oncology, 14, 1343839.

Publication 2024

PMOD v.4.3

Corresponding Organization : UiT The Arctic University of Norway

Other organizations : University Hospital of North Norway, Northern Norway Regional Health Authority

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Variable analysis

independent variables

MRI-based ROI

dependent variables

[18F]FDG activity concentration (Bq/ml)
Rate constants K1, k2, k3
Macro parameters MRGlu and Flux

control variables

Irreversible 2TCM (PMOD v.4.3, PMOD technologies)
Schwartz Criterion (SC), Akaike Information Criterion (AIK) and Model Selection Criterion (MSC)
Image derived input function (idIF) segmented from the inferior vena cava

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