All animal studies were carried out according to the protocol approved by the Animal and Care Committee at the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Db/db mice were purchased from Jackson Laboratory. Streptozotocin‐induced diabetic mice were generated as previously described (Sawaya et al, 2020 (link)). Both male and female mice were used in the wound healing studies. Treatments were performed at 7–9 weeks of age and all experiments were conducted using littermate controls.
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Diabetic Wound Healing Protocols
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Corresponding Organization :
Other organizations : National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, University of Miami, Dr. John T. Macdonald Foundation
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Variable analysis
independent variables
- Treatments
- Wound healing
- Age of mice (7–9 weeks)
- Use of littermate controls
- Positive control: Db/db mice
- Negative control: Streptozotocin-induced diabetic mice
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