PET Imaging of Tumor Glucose Metabolism

Early metabolic changes were assessed by PET scan with 2'-deoxy-2'-[¹⁸F]fluoro-D-glucose (¹⁸F-FDG). PET sessions were realized in a PET-CT scanner (nanoScan PET-CT; Mediso, Hungary) using 10 MBq of ¹⁸F-FDG (Advanced Applied Applications, France) as already published 1 (link). Quickly, tumor-bearing mice were fasted overnight, anesthetized (2 ± 0.5% isoflurane in air), weighed and glycaemia was measured in blood drawn from the caudal artery. ¹⁸F-FDG accumulation was quantified as mean SUV between 45 and 60 min post-injection in 3D volumes-of-interest (VOI) delineated semi-automatically by iso-contours at 45% threshold of maximal value in the myocardium on PET/CT fusion slices using the PMOD software package (PMOD Technologies Ltd, Zürich, Switzerland).

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Sourdon J., Facchin C., Certain A., Viel T., Robin B., Lager F., Marchiol C., Balvay D., Yoganathan T., Favier J., Tharaux P.L., Dhaun N., Renault G, & Tavitian B. (2021). Sunitinib-induced cardiac hypertrophy and the endothelin axis. Theranostics, 11(8), 3830-3838.

Publication 2021

nanoScan PET-CT PMOD software package

18f fdg Artery Blood Deoxy Glucose Isoflurane Mice Myocardium Pet ct Pet scan Tumor

Corresponding Organization :

Other organizations : Paris Cardiovascular Research Center, Centre de Résonance Magnétique Biologique et Médicale, Institut Cochin, Hôpital Européen Georges-Pompidou, Assistance Publique – Hôpitaux de Paris

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Variable analysis

independent variables

Fasting overnight
Anesthesia (2 ± 0.5% isoflurane in air)

dependent variables

Mean SUV between 45 and 60 min post-injection of 18F-FDG in 3D volumes-of-interest (VOI) delineated semi-automatically by iso-contours at 45% threshold of maximal value in the myocardium on PET/CT fusion slices

control variables

Tumor-bearing mice
Caudal artery blood glucose measurement
PET-CT scanner (nanoScan PET-CT; Mediso, Hungary)
18F-FDG (Advanced Applied Applications, France)
PMOD software package (PMOD Technologies Ltd, Zürich, Switzerland)

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