Operant Conditioning for Drug Self-Administration

Animals were tested in plexiglass operant chambers (Med Associates, St Albans, VT, USA), equipped with two levers. The required number of responses at the reinforced (Reinf) lever turned on a cue light over the lever, turned off the house light, and activated an externally mounted syringe pump that infused drug. During the infusion (5.6 s yielding 100 μl of solution) and timeout period (20 s) the cue light remained illuminated, and the house light remained off.
After the timeout period, the house light turned on and signaled the availability of a reinforcer. Responses on the non-reinforced (Non-Reinf) lever were recorded but had no consequences. Procedures modeled previous work (54 (link), 55 (link)).

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Carreño D, & Lotfipour S. (2023). Sex- and genotype-dependent nicotine plus cue-primed reinstatement is enhanced in adolescent Sprague Dawley rats containing the human CHRNA6 3′-UTR polymorphism (rs2304297). Frontiers in Psychiatry, 13, 1064211.

Publication 2022

plexiglass operant chambers

Animals Drug Light Plexiglass Syringe

Corresponding Organization : University of California, Irvine

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Variable analysis

independent variables

The required number of responses at the reinforced (Reinf) lever

dependent variables

Responses on the non-reinforced (Non-Reinf) lever
Drug infusion

control variables

Plexiglass operant chambers (Med Associates, St Albans, VT, USA) equipped with two levers
Cue light over the reinforced lever
House light
Externally mounted syringe pump that infused drug
Infusion duration (5.6 s) and timeout period (20 s)

positive controls

Procedures modeled previous work (54, 55)

Annotations

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