Vaginal Cancer Patients Retrospective Analysis

This study was conducted according to the guidelines of the Declaration of Helsinki and approved by the ethics committee of the Faculty of Medicine at the University of Bonn, Germany (Nr: 328/22). The institutional record database was screened for vaginal cancer patients treated at the Department of Gynecology and Gynecological Oncology between January 2010 and December 2021. Tissue collection was conducted within the Biobank initiative of the University of Bonn. The only inclusion criterion was a histologically confirmed diagnosis of a primary vaginal cancer. The only exclusion criterion was a history of vulvar or cervical cancer. All patients provided written informed consent before tissue collection. Baseline characteristics, pathology and therapeutic course were recorded from patient’s charts, surgery reports, radiation protocols and pathologic findings. Follow-up data were updated in July 2022. Histopathological diagnosis was determined based on World Health Organization (WHO) criteria, considering only patients with no prior history of a cervical or vulvar cancer [12 ]. Tumor stage was based on the 2018 revised International Federation of Gynecology and Obstetrics (FIGO) system and the TNM-Classification of the Union for International Cancer Control (UICC) [13 ,14 (link)].