Measuring Hemoglobin in UK Biobank Samples

Among samples collected at recruitment, hemoglobin concentrations (Field ID 30020, mg/dL) were measured in EDTA‐vacutainers using the Sysmex XN‐1000 hematology analyzer at the laboratory of the UK Biocenter (https://biobank.ctsu.ox.ac.uk/crystal/crystal/docs/haematology.pdf).
³⁵ (link),
³⁶ (link) The primary outcomes included incident cases of CAD, HF, IS, and T2D, which were identified through linkage to Hospital Episodes Statistics and mortality data, with diagnostic criteria defined by the International Classification of Diseases, Ninth Revision (ICD‐9) and Tenth Revision (ICD‐10) codes (Table S2). Data from UKB are available to bona fide researchers on application to https://www.ukbiobank.ac.uk. Data from other genetic consortia are also available on application to the relevant consortia.

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Liu Y., Clarke R., Bennett D.A., Zong G, & Gan W. (2024). Iron Status and Risk of Heart Disease, Stroke, and Diabetes: A Mendelian Randomization Study in European Adults. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 13(6), e031732.

Publication 2024

XN‐1000 hematology analyzer

Corresponding Organization :

Other organizations : Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, University of Oxford, Medical Research Council, Novo Nordisk (United Kingdom)

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Variable analysis

independent variables

Hemoglobin concentrations (Field ID 30020, mg/dL)

dependent variables

Incident cases of CAD (Coronary Artery Disease)
Incident cases of HF (Heart Failure)
Incident cases of IS (Ischemic Stroke)
Incident cases of T2D (Type 2 Diabetes)

control variables

Samples collected at recruitment were measured using the Sysmex XN-1000 hematology analyzer at the laboratory of the UK Biocenter

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