Standardized PET/CT Imaging Protocol for Breast Cancer

¹⁸F-fluorodeoxyglucose PET/CT imaging was performed from the skull base to the upper thigh at 50–70 min after intravenous administration of 5.2–7.4 MBq/kg (0.14–0.2 mCi/kg) of ¹⁸F-fluorodeoxyglucose^{22 (link)}. The median blood glucose level before ¹⁸F-fluorodeoxyglucose injection was 102 mg/dl (IQR 94–109). Two board-certified nuclear medicine physicians who were blinded to patient outcomes drew a volume of interest on the primary breast cancer or metastatic lymph nodes and assessed the maximum SUV of ¹⁸F-fluorodeoxyglucose uptake. The maximum standardized uptake values were harmonized across various PET/CT scanners (Biograph Sensation 16 and Biograph TruePoint 40, Siemens Healthineers, Knoxville, TN, USA; Discovery STE 8, Discovery PET/CT 690, and Discovery PET/CT 710, GE Healthcare, Milwaukee, WI, USA) without partial volume correction^{23 (link)}. The recovery coefficient profiles of variable-sized hot cylinders of the American College of Radiology-approved PET phantoms (i.e., Esser phantom) were matched^{24 (link),25 (link)}. Annual ¹⁸F water cylinder phantom-based cross-calibration between PET and dose calibrator assured the uniform standardized uptake value of 1.0 between PET scanners^{25 (link)}.

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Chae S.Y., Park S.H., Lee H.S., Ahn J.H., Kim S.B., Jung K.H., Kim J.E., Ahn S.H., Son B.H., Lee J.W., Ko B.S., Kim H.J., Gong G., Oh J.S., Park S.Y, & Moon D.H. (2022). Association between tumor 18F-fluorodeoxyglucose metabolism and survival in women with estrogen receptor-positive, HER2-negative breast cancer. Scientific Reports, 12, 7858.

Publication 2022

Biograph Sensation 16 Biograph TruePoint 40 Discovery PET/CT 690 Discovery PET/CT 710

18f fluorodeoxyglucose Blood glucose Breast cancer Intravenous administration Lymph nodes Nuclear medicine Patient Pet ct Physicians Skull base Thigh

Corresponding Organization :

Other organizations : Eulji University, Ulsan University Hospital, University of Ulsan, Ulsan College, Gangneung Asan Hospital, Asan Medical Center

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Variable analysis

independent variables

Intravenous administration of 5.2–7.4 MBq/kg (0.14–0.2 mCi/kg) of 18F-fluorodeoxyglucose

dependent variables

Maximum standardized uptake values (SUV) of 18F-fluorodeoxyglucose uptake in the primary breast cancer or metastatic lymph nodes

control variables

Blood glucose level before 18F-fluorodeoxyglucose injection (median 102 mg/dl, IQR 94–109)
Matching of recovery coefficient profiles of variable-sized hot cylinders of the American College of Radiology-approved PET phantoms (i.e., Esser phantom)
Annual 18F water cylinder phantom-based cross-calibration between PET and dose calibrator to ensure uniform standardized uptake value of 1.0 between PET scanners

controls

Positive control: American College of Radiology-approved PET phantoms (Esser phantom)
Negative control: Not explicitly mentioned

Annotations

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