Example 10

Formula 19 was used for excipient compatibility studies at stressed conditions (60° C. for 2 weeks) and the results are recorded in Table 12. A 3% loss occurred in the sample taken on the day of fill compounding and a 3% menthol loss occurred by the time the fill was encapsulated.

TABLE 12
Exemplary Liquisoft Composition
Formula 19Assay
(Talin-basedDextromethorphan
fill)HBrMentholDegradation Products
T099.9%97.4%Dextromethorphan: 0.01%
1 week at100.0%95.0%Dextromethorphan: 0.01%
60° C.RRT 0.95: 0.03%
2 weeks at99.7%93.5%Dextromethorphan: 0.01%
60° C.RRT 0.95: 0.03%

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