Nanocomposite Coating Application on Biomedical Devices

The nanocomposite, polyurethane-based MAAC was provided by TriPhyll, Inc. Hydrophobic SiO₂ nanoparticles, which are functionalized with polysiloxane, were dispersed in a two-part solvent-borne polyurethane coating. The liquid-phase MAAC was applied to the inner faces of PVC-DEHP containers (for RCC; Leukotrap RC system, Haemonetics, Boston, MA, USA) and BTHC-PVC (for PC; Reveos pooling set, Terumo BCT, Lakewood, CO, USA). The inner walls of the PC storage bags have one smooth and one textured surface. The MAAC was applied on the smoother side of the PC storage bags. For RCC units, both inner walls were textured, and the coating was applied on either side. For the other polymeric materials (PM) commonly used in biomedical devices (i.e., silicone and polyurethane), MAAC was applied directly on sections of 2500 mm [2 (link)]. Before each application, a 3-aminopropyl trimethoxy silane (APTMS) primer (Sigma; 2% APTMS, 6% distilled water and 92% isopropanol) was deposited on the surfaces to promote coating adhesion [42 (link)]. The liquid-phase MAAC was then added using a metallic rod specifically designed to apply a 50 µm-thick coating (with RD specialties) at the surface of each PM under study. Each MAAC-treated sample was then dried at 80 °C for one hour or until complete MAAC polymerization was reached.