Synthesis of 5-(8-methoxy-7-quinolyl)spiro[benzofuran-piperidine] Derivative

Example 166

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This compound was synthesized using 5-(8-methoxy-7-quinolyl)spiro[3H-benzofuran-2,4′-piperidine] 2HCl and O-methylhydroxylamine HCl Analysis: LCMS m/z=420 (M+1); ¹H NMR (400 MHz, DMSO-d₆) δ: 9.79 (s, 1H), 8.94 (dd, J=4.1, 1.6 Hz, 1H), 8.38 (dd, J=8.3, 1.8 Hz, 1H), 7.75 (d, J=8.8 Hz, 1H), 7.57 (d, J=8.3 Hz, 1H), 7.54 (dd, J=8.3, 4.3 Hz, 1H), 7.47 (d, J=1.3 Hz, 1H), 7.38 (dd, J=8.3, 2.0 Hz, 1H), 6.88 (d, J=8.3 Hz, 1H), 3.91 (s, 3H), 3.55 (s, 3H), 3.52-3.42 (m, 2H), 3.41-3.34 (m, 2H), 3.12 (s, 2H), 1.88-1.66 (m, 4H).

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US11878982B2. Spiropiperidine derivatives (2024-01-23). 89BIO LTD [IL]. Inventors: Robert L Hudkins [US], David B. Whitman [US], Craig A. Zificsak [US], Allison L. Zulli [US], Melody McWherter [US].

Patent 2024

1h nmr Benzofuran Dmso Lcms O methylhydroxylamine Piperidine

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Variable analysis

independent variables

5-(8-methoxy-7-quinolyl)spiro[3H-benzofuran-2,4'-piperidine] 2HCl
O-methylhydroxylamine HCl

dependent variables

Molecular weight (m/z=420 (M+1))
NMR spectra (1H NMR (400 MHz, DMSO-d6))

control variables

Not explicitly mentioned

controls

No positive or negative controls were mentioned in the given information.

Annotations

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