Carrageenan-Induced Pain Memory Model

In our previous study, the pain memory model was induced by two injections of carrageenan [2 (link), 3 (link)]. The first carrageenan injection was placed into the left hind paw plantar surface via the subcutaneous injection of 0.1 mL of 2% carrageenan (Sigma-Aldrich, St. Louis, MO, USA) to induce acute inflammatory pain. After a 14-day recovery period, when the right hind paw was also injected with the same carrageenan, the pain threshold of the recovered left hind paw dropped again. This shows that the pain memory model was successfully prepared. The basic experimental procedure is shown in Figure 1.

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Shen Z., Zhu Y., Liu B., Liang Y., He Q., Sun J., Wu Z., Zhang H., Yao S., He X., Fang J, & Shao X. (2019). Effects of Electroacupuncture on Pain Memory-Related Behaviors and Synchronous Neural Oscillations in the Rostral Anterior Cingulate Cortex in Freely Moving Rats. Neural Plasticity, 2019, 2057308.

Publication 2019

carrageenan

Acute pain Carrageenan Inflammatory Memory Pain Subcutaneous injection

Corresponding Organization : The Third Affiliated Hospital of Zhejiang Chinese Medical University

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Variable analysis

independent variables

First carrageenan injection into the left hind paw plantar surface
Second carrageenan injection into the right hind paw

dependent variables

Pain threshold of the recovered left hind paw

control variables

Subcutaneous injection of 0.1 mL of 2% carrageenan (Sigma-Aldrich, St. Louis, MO, USA)
14-day recovery period between the first and second carrageenan injections

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