Global gene expression profiling was performed in transiliac bone biopsies obtained from postmenopausal white women from Oslo, as described.(36 (link)) This permitted us to calculate the correlation values between hip geometry SNPs (and their proxies) and the transcript levels of genes in the vicinity of the identified loci. In brief, the women undergoing bone biopsies (50 to 86 years old) were free from diseases other than osteoporosis or receiving medication (past or present) possibly affecting bone remodeling or representing secondary causes of osteoporosis.(36 (link),37 (link)) RNA was purified and analyzed using Affymetrix HG U133 2.0 plus arrays as described.(36 (link)) Bone total RNA was subjected to global transcript profiling using HG-U133 plus 2.0 microarrays (Affymetrix). These data are available at the European Bioinformatics Institute (EMBL-EBI) ArrayExpress repository, ID: E-MEXP-1618 (http://www.ebi.ac.uk/arrayexpress/experiments/E-MEXP-1618/).(17 (link),38 (link)) DXA scans from the bone donors were subjected to HSA. Filtered transcript levels from 80 bone biopsies were correlated with hip geometry data; results were adjusted for multiple testing using false-discovery rate (FDR).