Echocardiographic Analysis of Cardiac Function

An echocardiographic study was performed at day 5 after the MI procedure using a Vevo770 system (Visual Sonics Inc.) with 17.5-MHz transducers as described previously [20 (link)]. The rats were anesthetized with 7% chloral hydrate (35 mg/kg i.p; n =6 per group) and placed in the supine position. A cardiologist who was blinded to the drug treatment evaluated the cardiac function of the rats. The left ventricular internal dimension in systole (LVIDs), left ventricular internal dimension in diastole (LVIDd), left ventricular anterior wall in systole (LVAWs), left ventricular anterior wall in diastole (LVAWd), left ventricular posterior wall in systole (LVPWs), left ventricular posterior wall in diastole (LVPWd), left ventricular volume in systole (LVs), left ventricular volume in diastole (LVd), ejection fraction (EF) and fractional shortening (FS) were measured using the M-mode tracings of the high-resolution electrocardiograph system.

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Tran B.H., Huang C., Zhang Q., Liu X., Lin S., Liu H., Wang S, & Zhu Y.Z. (2015). Cardioprotective effects and pharmacokinetic properties of a controlled release formulation of a novel hydrogen sulfide donor in rats with acute myocardial infarction. Bioscience Reports, 35(3), e00216.

Publication 2015

Vevo770 system

Cardiac Cardiologist Chloral hydrate Diastole Drug Echocardiographic Electrocardiograph Left ventricular Rats Systole Transducers

Corresponding Organization :

Other organizations : Fudan University, Shenyang Pharmaceutical University

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Variable analysis

independent variables

The independent variable is not explicitly mentioned.

dependent variables

Left ventricular internal dimension in systole (LVIDs)
Left ventricular internal dimension in diastole (LVIDd)
Left ventricular anterior wall in systole (LVAWs)
Left ventricular anterior wall in diastole (LVAWd)
Left ventricular posterior wall in systole (LVPWs)
Left ventricular posterior wall in diastole (LVPWd)
Left ventricular volume in systole (LVs)
Left ventricular volume in diastole (LVd)
Ejection fraction (EF)
Fractional shortening (FS)

control variables

The rats were anesthetized with 7% chloral hydrate (35 mg/kg i.p; n =6 per group) and placed in the supine position.
A cardiologist who was blinded to the drug treatment evaluated the cardiac function of the rats.

positive controls

No positive controls were explicitly mentioned.

negative controls

No negative controls were explicitly mentioned.

Annotations

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