In this study, the volumes (in cubic millimeters) of total brain, gray matter, white matter, hippocampus, and WMH were assessed. Extreme outlying data points (further than ±4 standard deviations [SD] from the mean) were excluded (0.002% of the total imaging-derived phenotype data analyzed). All MRI parameters were converted to z-scores, and WMH volume was log-transformed due to its skewed distribution.
MRI Brain Structures and Volumes
In this study, the volumes (in cubic millimeters) of total brain, gray matter, white matter, hippocampus, and WMH were assessed. Extreme outlying data points (further than ±4 standard deviations [SD] from the mean) were excluded (0.002% of the total imaging-derived phenotype data analyzed). All MRI parameters were converted to z-scores, and WMH volume was log-transformed due to its skewed distribution.
Corresponding Organization : Karolinska Institutet
Other organizations : Army Medical University
Variable analysis
- None explicitly mentioned
- Volume of total brain
- Volume of gray matter
- Volume of white matter
- Volume of hippocampus
- Volume of white matter hyperintensities (WMH)
- Imaging centers (Cheadle, Reading, Newcastle, and Bristol)
- Siemens Skyra 3T scanner with a standard Siemens 32-channel head coil
- T1-weighted imaging (resolution: 1.0 × 1.0 × 1.0 mm; field-of-view: 208 × 256 × 256 matrix)
- T2 FLAIR imaging (resolution: 1.05 × 1.0 × 1.0 mm; field-of-view: 192 × 256 × 256 matrix)
- Image-processing pipeline developed and run on behalf of the UK Biobank, using FMRIB Software Library (version 5.0.10) and FreeSurfer (version 6.0)
- Exclusion of extreme outlying data points (further than ±4 standard deviations from the mean; 0.002% of the total imaging-derived phenotype data analyzed)
- Conversion of all MRI parameters to z-scores
- Log-transformation of WMH volume due to its skewed distribution
- None explicitly mentioned
- None explicitly mentioned
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