Genome-Wide Genotyping and Imputation

All genotype data were approved and provided by the National Biobank of Korea and the Centers for Disease Control and Prevention, the Republic of Korea (no. 2019-022). Genotyping in the Ansung–Ansan cohort study was performed using the Affymetrix genome-wide human SNP array 5.0, and genotype imputation was performed using IMPUTE2; the 1000 genome projects of the East Asian ancestry sample was used as a reference panel. Genotyping in the HEXA study was performed using the Korean Chip designed by the Center for Genome Science at the Korean National Institutes of Health. The expected genotyping and quality-control information has been described previously in detail^{29 (link),30 (link)}.

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Park J.Y., Yoo M.G., Yun J.H., Lee H.J, & Park S.I. (2021). Synergistic effect between the KCNQ1 haplotype and alcohol consumption on the development of type 2 diabetes mellitus in Korean cohorts. Scientific Reports, 11, 21796.

Publication 2021

genome-wide human SNP array 5.0

Asian ancestry Chip East asian Genome Genome human Hexa Korean

Corresponding Organization :

Other organizations : Korea Disease Control and Prevention Agency, Korea National Institute of Health

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Variable analysis

independent variables

Genotyping using the Affymetrix genome-wide human SNP array 5.0 in the Ansung–Ansan cohort study
Genotyping using the Korean Chip designed by the Center for Genome Science at the Korean National Institutes of Health in the HEXA study

dependent variables

Not explicitly mentioned

control variables

Genotype imputation performed using IMPUTE2 in the Ansung–Ansan cohort study
1000 genome projects of the East Asian ancestry sample used as a reference panel in the Ansung–Ansan cohort study

positive controls

Not specified

negative controls

Not specified

Annotations

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