Postmortem Brain Imaging at 7T

All scans of postmortem tissue were performed at Western's Centre for Functional and Metabolic Mapping on a 7T Scanner (Siemens) following a previously described imaging protocol [33 (link)]. Briefly, frontal coronal sections were selected from each fixed brain and immersed in Galden HT‐270 perfluorinated fluid in a custom‐stacking device for imaging. T1‐weighted images from a MP2RAGE sequence, with an extended T1 time to improve contrast, and FLAIR images from a T2 SPACE sequence were acquired.

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Roseborough A.D., Rasheed B., Jung Y., Nishimura K., Pinsky W., Langdon K.D., Hammond R., Pasternak S.H., Khan A.R, & Whitehead S.N. (2021). Microvessel stenosis, enlarged perivascular spaces, and fibrinogen deposition are associated with ischemic periventricular white matter hyperintensities. Brain Pathology, 32(1), e13017.

Publication 2021

7T Scanner

Brain Device Postmortem Scans Tissue

Corresponding Organization : Western University

Other organizations : McMaster University, University of Calgary

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

T1-weighted images from a MP2RAGE sequence
FLAIR images from a T2 SPACE sequence

control variables

Fixed brain samples
Galden HT-270 perfluorinated fluid
Custom-stacking device for imaging
7T Scanner (Siemens)

controls

None explicitly mentioned

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