Medline bibliographic database including PubMed, Embase, and the Cochrane Central Register of Controlled trials in Cochrane Library published between January 2004 and January 2017 were searched using the following key words : “ischemic stroke”, “endovascular therapy”, “cerebral infarct”, “intra-venous”, “intra-arterial”, “fibrinolysis”[5 (link)], “thrombolysis”, “thrombectomy”, “bridging thrombolysis”, “IV Tpa”, “hemorrhage”, “embolus”, “eath”, “peri-operative complications”, and “mortality”.