18F-Florzolotau PET Imaging for Tau Assessment

All eligible participants underwent ¹⁸F-Florzolotau tau PET imaging and T1-weighted MR imaging within 2 weeks from the baseline visit. The tosylate precursor of the tracer was obtained from APRINOIA Therapeutics (Suzhou, China). Because of its light sensitivity, both manufacturing and injection of ¹⁸F-Florzolotau were carried out under a green light-emitting diode (510 nm) [10 (link)]. ¹⁸F-Florzolotau tau PET imaging was acquired using a 20-min protocol (90 − 110 min) on a Biograph mCT Flow PET/CT system (Siemens Healthcare GmbH, Erlangen, Germany) and reconstructed using a 3D-ordered subset expectation maximization algorithm. T1-weighted MR imaging was acquired using a 3.0-T horizontal magnet (Discovery MR750; GE Medical Systems, Milwaukee, WI, USA). The details for imaging acquisition could be found in the previous publication [11 (link)].