Myriocin-Loaded Lipid Nanoparticles

myriocin (Myr) from Mycelia sterilia ≥ 98% (HPLC) powder was purchased from Sigma-Aldrich (Milan, Italy); 14-hydroxy-myriocin was prepared in our laboratory by chemical reduction of the carbonyl group, purified and characterized by mass spectrometry. Sphingolipids standards were purchased by Avanti Polar Lipids (Alabaster, USA). Gelucire® 44/14 (lauroyl polyoxyl-32 glycerides) was donated by Gattefossè (France). Mygliol 812® (triglyceride capric/caprylic acids) was purchased from Farmalabor (Italy). Tween 80 and benzalkonium chloride were purchased from Sigma-Aldrich (Milan, Italy).
Methanol (MeOH), acetonitrile, ammonium formate, acetic acid, potassium hydroxide (KOH) and formic acid (all of analytical grade) were supplied by Merck (Darmstadt, Germany). Water was MilliQ grade.

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Platania C.B., Dei Cas M., Cianciolo S., Fidilio A., Lazzara F., Paroni R., Pignatello R., Strettoi E., Ghidoni R., Drago F, & Bucolo C. (2019). Novel ophthalmic formulation of myriocin: implications in retinitis pigmentosa. Drug Delivery, 26(1), 237-243.

Publication 2019

myriocin Tween 80 benzalkonium chloride Methanol (MeOH), acetonitrile ammonium formate potassium hydroxide (KOH) formic acid

Acetic acid Acetonitrile Alabaster Ammonium formate Benzalkonium chloride Capric acids Caprylic acids Formic acid Gelucire 44 14 Glycerides Hplc Lipids Mass spectrometry Methanol Mycelia Myriocin Potassium hydroxide Powder Sphingolipids Triglyceride Tween 80

Corresponding Organization : University of Catania

Other organizations : University of Milan

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Variable analysis

independent variables

Myriocin (Myr) from Mycelia sterilia ≥ 98% (HPLC) powder
14-hydroxy-myriocin prepared by chemical reduction of the carbonyl group

dependent variables

Not explicitly mentioned

control variables

Sphingolipids standards purchased from Avanti Polar Lipids
Gelucire® 44/14 (lauroyl polyoxyl-32 glycerides) donated by Gattefossè
Mygliol 812® (triglyceride capric/caprylic acids) purchased from Farmalabor
Tween 80 and benzalkonium chloride purchased from Sigma-Aldrich
Methanol (MeOH), acetonitrile, ammonium formate, acetic acid, potassium hydroxide (KOH) and formic acid (all of analytical grade) supplied by Merck
Water of MilliQ grade

controls

Positive control: Not mentioned
Negative control: Not mentioned

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