The “Coronary Evaluation Using Multidetector Spiral Computed Tomography Angiography using 64 Detectors” or “CORE-64” study was designed to evaluate the diagnostic accuracy of multislice spiral CT angiography using 64 detector rows for identifying coronary artery stenosis in patients with suspected or known significant coronary artery disease. The study was designed as a prospective, multi-centre (nine centres), international (seven countries) study examining the diagnostic accuracy of 64-slice CT in comparison with CCA. The primary hypothesis of the study was that 64-slice CT coronary angiography will be able to detect significant coronary artery disease in a patient with acceptable diagnostic accuracy as compared to CCA. Significant CAD is defined as ≥50% stenosis as determined by coronary angiography (QCA) of CCA. The primary diagnostic parameters were per-patient sensitivity and specificity compared with CCA. These were analysed using both point estimates and continuous measurements (using area under the receiver-operating characteristics curve) expressed with 95% confidence intervals for the corresponding true values to indicate the precision of the estimates. We also compared the diagnostic performance of CCA with that of MSCT for anatomy-based prediction of subsequent clinically driven revascularisation on a per-patient and per-vessel level. Other secondary objectives include the evaluation of diagnostic accuracy based on a per-vessel and per-segment unit of analysis, and defining significant stenosis at both ≥50% and ≥70% thresholds, with QCA as the reference standard.