Participants presenting with comorbidity of neuropsychological disorders (eg, PTSD, dementia) or with a diagnosis of depression secondary to medical illnesses were excluded. Participants were also excluded if they presented with acute suicidality or underwent electroconvulsive therapy within the current depressive episode. The full list of inclusion and exclusion criteria is presented in
Evaluating a Novel Intervention for Treatment-Resistant Depression
Participants presenting with comorbidity of neuropsychological disorders (eg, PTSD, dementia) or with a diagnosis of depression secondary to medical illnesses were excluded. Participants were also excluded if they presented with acute suicidality or underwent electroconvulsive therapy within the current depressive episode. The full list of inclusion and exclusion criteria is presented in
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Corresponding Organization : St. Michael's Hospital
Other organizations : Public Health Ontario
Variable analysis
- Treatment condition (experimental vs. control)
- Response to treatment, as measured by the Hamilton Depression Rating Scale (HAMD) score
- Maintaining current antidepressant regimen 28 days before screening and during the study
- Use of highly effective or double-barrier contraceptive methods for women of childbearing potential
- Excluding participants with comorbidity of neuropsychological disorders (e.g., PTSD, dementia) or with a diagnosis of depression secondary to medical illnesses
- Excluding participants with acute suicidality or who underwent electroconvulsive therapy within the current depressive episode
- Positive control: Participants required to have a score of 18 or greater on the Hamilton Depression Rating Scale (HAMD)
- Negative control: None explicitly mentioned
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