Micro-CT Analysis of Femur Bone Microstructure

In order to evaluate the bone microstructure, the right femur was analyzed with high-resolution micro-CT using the micro-CT imaging system (Siemens, Inveon) according to the method described in the literature (Zhang et al., 2012 (link)). The femur was fixed in the centrifuge tube by the long axis, while the surrounding was filled with gauze. Quantitative parameters of bone microstructure including percent bone volume (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N), trabecular separation (Tb.Sp), structural model index (SMI) and bone mineral density (BMD) were measured. All the digital data, 2 D and 3 D images were provided by the built-in software of micro-CT (Siemens, Inveon).

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Xi Y., Wang W., Ma L., Xu N., Shi C., Xu G., He H, & Pan W. (2022). Alendronate modified mPEG-PLGA nano-micelle drug delivery system loaded with astragaloside has anti-osteoporotic effect in rats. Drug Delivery, 29(1), 2386-2402.

Publication 2022

Inveon

Axis Bone Bone mineral density Femur Micro ct Trabecular

Corresponding Organization : Changshu No.1 People's Hospital

Other organizations : Sixth Affiliated Hospital of Xinjiang Medical University, Xinjiang Medical University

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Percent bone volume (BV/TV)
Trabecular thickness (Tb.Th)
Trabecular number (Tb.N)
Trabecular separation (Tb.Sp)
Structural model index (SMI)
Bone mineral density (BMD)

control variables

The right femur was the sample analyzed
The femur was fixed in the centrifuge tube by the long axis
The surrounding was filled with gauze

controls

No positive or negative controls were explicitly mentioned

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