The objective of this study was to carry out a multi-country concurrent accuracy evaluation of the ADVIA Centaur® Syphilis CLIA assay (Siemens Healthcare) compared to the reference TPPA (SERODIA-TP·PA®; Fujirebio Diagnostics) for syphilis screening (serum samples) amongst a sample of MSM attending the Infectious Disease Department in Verona (Italy), the GenitoUrinary (GU)-clinic in the Mater Dei Hospital, L-Imsida (Malta) and the Brighton & Hove Sexual Health and Contraception Service (SHAC) in Brighton (UK). Using the same protocol and criteria, an additional sample of patients (MSM) was enrolled at the Verona site in the framework of an EU-funded project called Sialon [11 (link)].
Gios L., Mirandola M., Cordioli M., Zorzi A., Sherriff N., Vera J., Wlazly D., Hassan-Ibrahim M.O., Padovese V., A.n.a.b.e.l. .D.a.r.m.a.n.i.n., Peeling R.W., Unemo M., Blondeel K, & Toskin I. (2024). A multi-country comparative study of two treponemal tests for the serodiagnosis of syphilis amongst men who have sex with men (MSM): Chemo-luminescent assay vs Treponema pallidum particle agglutination assay. BMC Infectious Diseases, 24(Suppl 1), 313.
Other organizations :
University of Brighton, Brighton and Sussex Medical School, University of Sussex, University Hospitals Sussex NHS Foundation Trust, Royal Sussex County Hospital, Mater Dei Hospital, London School of Hygiene & Tropical Medicine, Örebro University, World Health Organization
Accuracy of the ADVIA Centaur® Syphilis CLIA assay compared to the reference TPPA (SERODIA-TP·PA®; Fujirebio Diagnostics) for syphilis screening
control variables
Sample of MSM attending the Infectious Disease Department in Verona (Italy), the GenitoUrinary (GU)-clinic in the Mater Dei Hospital, L-Imsida (Malta) and the Brighton & Hove Sexual Health and Contraception Service (SHAC) in Brighton (UK)
Additional sample of patients (MSM) enrolled at the Verona site in the framework of an EU-funded project called Sialon
positive controls
TPPA (SERODIA-TP·PA®; Fujirebio Diagnostics)
negative controls
Not specified
Annotations
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